Result: Positive immune response &
Improved response to previously failed traditional therapies
Exposure to a medically induced high fever, under the HEATT® procedure stimulates innate immune pathways as indicated by cytokine signaling. This upregulation of the immune response contributes to the body’s natural defenses, attacking the cancer cells remaining. Data collected from autopsy showed tumor infiltration by lymphocytes in the ovarian trial and implies this natural process as a benefit of HEATT®.
Seven patients received chemotherapy regimens after completing HEATT®. All seven responded to chemotherapy regimens that they had failed previously (before HEATT®), including localized hyperthermia, radiation therapies, and chemotherapies. The increase in survival suggests at least a re-set of molecular mechanisms know as thermal sensitization.