Hyperthermia Procedure

• 4 to 5-hour procedure kills Cancer Cells.

• Controlled homogeneous heat distribution.

• Detoxify blood and restore normalized blood chemistry. 

Hyperthermia by HEATT™

Heats patients from the inside!

• Heat the blood in the perfusion circuit that uniformly heats at the body.

• Proprietary process, HEATT™­­ to control 42°C. (107.6° F) 

Hyperthermic 

Extracorporeal Applied Tumor Treatment or HEATT™

• HEATT™ can be safely delivered.

• HEATT™ destroys tumor cells at the primary cancer site.

• HEATT™ destroys metastasizing cells.

• HEATT™ increases survival in our FDA Phase I Trial.

• HEATT™ improves the quality of life in our Trial.

• HEATT™ may increase the efficacy of other treatments.

Target: Are Cancer Cells Heat Sensitive?

Early Experiment

• Quantify surviving cells.

• 42°C for 120 minutes.

• Cancer cell lines had significant reduction in survivors.

• Normal not affected.

• From solid organs - colon, liver, ovary, lung, pancreas, and liver.

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HEATT™

(formerly VV-PISH)

UTMB Laboratory Studies

• Rapid induction (~30 min) to homogeneous heat distribution.

       ASAIO J 42:250, 1996

• Dialysis with sorbent normalizes serum chemistries.  

       ASAIO J 43:806, 1997

• Multipoint monitoring with feedback temperature control allows predictable thermal dosimetry.   

       Ann Thorac Surg 70:644, 2000

• Lung cancer cells susceptible to hyperthermia.          

       Ann Thorac Surg 69:1675, 2000

Total Body Hyperthermia Publications

• 17 Peer-reviewed Publications and 1 Book Chapter

           -   Vertrees / Zwischenberger

           -   Wang / Zwischenberger

• ASAIO J 1996; 42:250

• Perfusion 1996;11:425

• ASAIO J 1997;43:M806

• Arch Clin Neuropsychol 2000;15:668

• Ann Thorac Surg 2000;70:644

• Perfusion 2001;16:243

• Ann Thorac Surg 2001;72:234

• Perfusion 2002;17(4):279

• Ann Thorac Surg 2004; 77(6): 1916

• Cancer Biol Ther 2005;4(10):e52

• Mol Carcinog 2005;44(2):111

• Post 2005 – Pursuing Market Entrance