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Medical Science
HEATT
™

Hyperthermia Procedure

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4 to 5-hour procedure kills Cancer Cells.
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Controlled homogeneous heat distribution.
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Detoxify blood and restore normalized blood chemistry.

Hyperthermia by HEATT™
Heats patients from the inside!
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Heat the blood in the perfusion circuit that uniformly heats at the body.
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Proprietary process, HEATT™ to control 42°C. (107.6° F)

Hyperthermic
Extracorporeal Applied Tumor Treatment or HEATT™
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HEATT™ can be safely delivered.
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HEATT™ destroys tumor cells at the primary cancer site.
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HEATT™ destroys metastasizing cells.
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HEATT™ increases survival in our FDA Phase I Trial.
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HEATT™ improves the quality of life in our Trial.
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HEATT™ may increase the efficacy of other treatments.

Target: Are Cancer Cells Heat Sensitive?
Early Experiment
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Quantify surviving cells.
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42°C for 120 minutes.
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Cancer cell lines had significant reduction in survivors.
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Normal not affected.
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From solid organs - colon, liver, ovary, lung, pancreas, and liver.

HEATT™
(formerly VV-PISH)
UTMB Laboratory Studies
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Rapid induction (~30 min) to homogeneous heat distribution.
ASAIO J 42:250, 1996
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Dialysis with sorbent normalizes serum chemistries.
ASAIO J 43:806, 1997
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Multipoint monitoring with feedback temperature control allows predictable thermal dosimetry.
Ann Thorac Surg 70:644, 2000
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Lung cancer cells susceptible to hyperthermia.
Ann Thorac Surg 69:1675, 2000

Total Body Hyperthermia Publications
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17 Peer-reviewed Publications and 1 Book Chapter
- Vertrees / Zwischenberger
- Wang / Zwischenberger
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ASAIO J 1996; 42:250
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Perfusion 1996;11:425
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ASAIO J 1997;43:M806
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Arch Clin Neuropsychol 2000;15:668
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Ann Thorac Surg 2000;70:644
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Perfusion 2001;16:243
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Ann Thorac Surg 2001;72:234
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Perfusion 2002;17(4):279
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Ann Thorac Surg 2004; 77(6): 1916
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Cancer Biol Ther 2005;4(10):e52
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Mol Carcinog 2005;44(2):111
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Post 2005 – Pursuing Market Entrance

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