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Hyperthermia Procedure

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  • 4 to 5-hour procedure kills Cancer Cells.

  • Controlled homogeneous heat distribution.

  • Detoxify blood and restore normalized blood chemistry. 

lab technician assistant analyzing a blo

Hyperthermia by HEATT™

Heats patients from the inside!

  • Heat the blood in the perfusion circuit that uniformly heats at the body.

  • Proprietary process, HEATT™­­ to control 42°C. (107.6° F) 

Ovarian Cancer Awareness: Micrograph of

Hyperthermic 

Extracorporeal Applied Tumor Treatment or HEATT™

  • HEATT™ can be safely delivered.

  • HEATT™ destroys tumor cells at the primary cancer site.

  • HEATT™ destroys metastasizing cells.

  • HEATT™ increases survival in our FDA Phase I Trial.

  • HEATT™ improves the quality of life in our Trial.

  • HEATT™ may increase the efficacy of other treatments.

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Target: Are Cancer Cells Heat Sensitive?

Early Experiment

  • Quantify surviving cells.

  • 42°C for 120 minutes.

  • Cancer cell lines had significant reduction in survivors.

  • Normal not affected.

  • From solid organs - colon, liver, ovary, lung, pancreas, and liver.

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HEATT™

(formerly VV-PISH)

UTMB Laboratory Studies

  • Rapid induction (~30 min) to homogeneous heat distribution.

       ASAIO J 42:250, 1996

  • Dialysis with sorbent normalizes serum chemistries.  

       ASAIO J 43:806, 1997

  • Multipoint monitoring with feedback temperature control allows predictable thermal dosimetry.   

       Ann Thorac Surg 70:644, 2000

  • Lung cancer cells susceptible to hyperthermia.          

       Ann Thorac Surg 69:1675, 2000

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Total Body Hyperthermia Publications

  • 17 Peer-reviewed Publications and 1 Book Chapter

           -   Vertrees / Zwischenberger

           -   Wang / Zwischenberger

  • ASAIO J 1996; 42:250

  • Perfusion 1996;11:425

  • ASAIO J 1997;43:M806

  • Arch Clin Neuropsychol 2000;15:668

  • Ann Thorac Surg 2000;70:644

  • Perfusion 2001;16:243

  • Ann Thorac Surg 2001;72:234

  • Perfusion 2002;17(4):279

  • Ann Thorac Surg 2004; 77(6): 1916

  • Cancer Biol Ther 2005;4(10):e52

  • Mol Carcinog 2005;44(2):111

  • Post 2005 – Pursuing Market Entrance

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